Cytoxan and canine anal gland carcinoma










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Despite the low toxicity of this kind of protocol, it is known that some animals may develop non-infectious hemorrhagic cystitis, secondary to chronic cyclophosphamide administration Kerbel and Kamen, Veterinary Oncology has evolved in the past few years, and the number of patients treated with conventional chemotherapy using maximum tolerated doses MTD is increasing. Conventional chemotherapy treatment in dogs and cats uses the same drugs used in Medicine protocols, including intervals and administration routes. Introduction to small animal oncology. Services on Demand Journal.

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Apocrine Gland Carcinoma Of The Anal Sac

COX-2 is mainly expressed when it is induced by many stimuli, such as tumor promoters, oncogenes and carcinogens Horta et al. Treatment showed effectiveness, since the patient's overall survival exceeded days 36 months , considerably higher than the mean overall survival expected for this pathology. Initial and final size variation is not significant, indicating a stable disease. It was concluded that COX-2 is expressed in glandular epithelial cells of canine anal sac carcinoma and in non-neoplastic anal sac cells, which indicates that this enzyme may have a physiological role in this tissue. Conventional chemotherapy treatment in dogs and cats uses the same drugs used in Medicine protocols, including intervals and administration routes. Male and female dogs have a similar risk for the development of anal sac apocrine carcinoma Bennett et al. Clinical follow up was kept every 60 days.

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A ten-year-old female Labrador retriever was first evaluated in October with a history of surgically treated mammary tumors, hypothyroidism treated with levothyroxine and a perianal nodule noticed by the owner 15 days earlier. Despite the low toxicity of this kind of protocol, it is known that some animals may develop non-infectious hemorrhagic cystitis, secondary to chronic cyclophosphamide administration Kerbel and Kamen, Canine anal sac apocrine carcinoma is a malignant tumor originated from apocrine glands on the anal sac walls. It was then decided to avoid a new surgical procedure. The nodule was approximately 5cm in diameter, fast growing, well delimitated, movable and firm.

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Description: Lymph node microscopic examination revealed epithelial proliferation with predominantly tubular and solid disposition. Veterinary Oncology has evolved in the past few years, and the number of patients treated with conventional chemotherapy using maximum tolerated doses MTD is increasing. However, due to the cost and availability limitations, these exams were not performed. Initial and final size variation is not significant, indicating a stable disease. Primary mass and lymph node were submitted to histopathological examination. More studies are necessary to evaluate the effect of this treatment association in a larger population.
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